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1467: Extra Large Monomer Design

Closed since about 8 years ago

Summary

Created: January 05, 2018
Expires: January 12, 2018 at 23:00 UTC
Max points: 100

Description

This puzzle challenges players to design a protein with 95-120 residues. We've softened the penalties associated with the Core Existence and Residue Count filters, which have typically been very steep. The starting structure has 95 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. freefolder 1 pt. 7,069
12. Trinity Biology 1 pt. 6,497
13. Deleted group pts. 2,164
14. DSN @ Home 1 pt. 0

31. Deleted player pts. 9,850
32. georg137 Lv 1 20 pts. 9,717
33. alcor29 Lv 1 19 pts. 9,593
34. Sissue Lv 1 18 pts. 9,542
35. toshiue Lv 1 17 pts. 9,516
36. dizzywings Lv 1 16 pts. 9,498
37. Cagdason Lv 1 15 pts. 9,491
38. WBarme1234 Lv 1 14 pts. 9,408
39. fishercat Lv 1 13 pts. 9,370
40. Dijkgraaf Lv 1 12 pts. 9,311

Comments

bkoep Staff Lv 1

January 05, 2018

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."