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1491: Large Monomer Design

Closed since about 8 years ago

Intermediate Intermediate Overall Overall Design Design

Summary

Created
March 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Trinity Biology 11. Trinity Biology 1 pt. 4,345
  2. Avatar for Deleted group 12. Deleted group pts. 2,303
  3. Avatar for Richard Dawkins Foundation 13. Richard Dawkins Foundation 1 pt. 1,456
  1. Avatar for isaksson 21. isaksson Lv 1 41 pts. 10,114
  2. Avatar for dcrwheeler 22. dcrwheeler Lv 1 39 pts. 10,096
  3. Avatar for jausmh 23. jausmh Lv 1 37 pts. 10,026
  4. Avatar for Anfinsen_slept_here 24. Anfinsen_slept_here Lv 1 35 pts. 10,012
  5. Avatar for Mike Cassidy 25. Mike Cassidy Lv 1 33 pts. 9,966
  6. Avatar for NinjaGreg 26. NinjaGreg Lv 1 32 pts. 9,941
  7. Avatar for alwen 27. alwen Lv 1 30 pts. 9,937
  8. Avatar for smilingone 28. smilingone Lv 1 28 pts. 9,935
  9. Avatar for senor pit 29. senor pit Lv 1 27 pts. 9,914
  10. Avatar for robgee 30. robgee Lv 1 26 pts. 9,814

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.