1491: Large Monomer Design

Closed since about 8 years ago

Summary

• Created: March 03, 2018
• Expires: March 09, 2018 at 23:00 UTC
• Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Gargleblasters 100 pts. 10,617
• 2. Beta Folders 65 pts. 10,617
• 3. Go Science 41 pts. 10,565
• 4. Void Crushers 24 pts. 10,496
• 5. Contenders 14 pts. 10,480
• 6. Anthropic Dreams 7 pts. 10,414
• 7. Marvin's bunch 4 pts. 10,026
• 8. L'Alliance Francophone 2 pts. 9,650
• 9. freefolder 1 pt. 7,582
• 10. GENE 433 1 pt. 6,642

Top soloists

• 1. Enzyme 100 pts. 10,617
• 2. LociOiling 96 pts. 10,617
• 3. ZeroLeak7 92 pts. 10,565
• 4. Madde 89 pts. 10,496
• 5. Bletchley Park 85 pts. 10,480
• 6. Timo van der Laan 81 pts. 10,459
• 7. retiredmichael 78 pts. 10,453
• 8. johnmitch 75 pts. 10,410
• 9. Galaxie 71 pts. 10,407
• 10. Skippysk8s 68 pts. 10,398

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.