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1491: Large Monomer Design

Closed since about 8 years ago

Intermediate Overall Design

Summary

Created
March 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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    1. Gargleblasters
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  1. Avatar for alcor29 41. alcor29 Lv 1 14 pts. 9,422
  2. Avatar for weitzen 42. weitzen Lv 1 13 pts. 9,396
  3. Avatar for phi16 43. phi16 Lv 1 12 pts. 9,304
  4. Avatar for SKSbell 44. SKSbell Lv 1 11 pts. 9,278
  5. Avatar for Maerlyn138 45. Maerlyn138 Lv 1 11 pts. 9,263
  6. Avatar for momadoc 46. momadoc Lv 1 10 pts. 9,262
  7. Avatar for Merf 47. Merf Lv 1 9 pts. 9,145
  8. Avatar for WBarme1234 48. WBarme1234 Lv 1 9 pts. 9,125
  9. Avatar for Fat Tony 49. Fat Tony Lv 1 8 pts. 9,042
  10. Avatar for SouperGenious 50. SouperGenious Lv 1 8 pts. 9,016

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.