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1513: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 24, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 11. DSN @ Home 1 pt. 1,633
  2. Avatar for Team China 12. Team China 1 pt. 0
  3. Avatar for Window Group 13. Window Group 1 pt. 0
  1. Avatar for momadoc 41. momadoc Lv 1 9 pts. 10,802
  2. Avatar for silent gene 42. silent gene Lv 1 8 pts. 10,788
  3. Avatar for ManVsYard 43. ManVsYard Lv 1 8 pts. 10,773
  4. Avatar for weitzen 44. weitzen Lv 1 7 pts. 10,705
  5. Avatar for alwen 45. alwen Lv 1 7 pts. 10,658
  6. Avatar for dbuske 46. dbuske Lv 1 6 pts. 10,584
  7. Avatar for Deleted player 47. Deleted player pts. 10,516
  8. Avatar for ourtown 48. ourtown Lv 1 5 pts. 10,383
  9. Avatar for SouperGenious 49. SouperGenious Lv 1 5 pts. 10,349
  10. Avatar for DoctorSockrates 50. DoctorSockrates Lv 1 4 pts. 10,274

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.