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1513: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
April 24, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 11. DSN @ Home 1 pt. 1,633
  2. Avatar for Team China 12. Team China 1 pt. 0
  3. Avatar for Window Group 13. Window Group 1 pt. 0
  1. Avatar for Gra4ON 71. Gra4ON Lv 1 1 pt. 8,618
  2. Avatar for Merf 72. Merf Lv 1 1 pt. 8,525
  3. Avatar for ghiggins 73. ghiggins Lv 1 1 pt. 8,518
  4. Avatar for Anamfija 74. Anamfija Lv 1 1 pt. 8,456
  5. Avatar for johngran 75. johngran Lv 1 1 pt. 8,330
  6. Avatar for rinze 76. rinze Lv 1 1 pt. 8,001
  7. Avatar for JeNNeR 77. JeNNeR Lv 1 1 pt. 7,440
  8. Avatar for larry25427 78. larry25427 Lv 1 1 pt. 6,872
  9. Avatar for cherry39 79. cherry39 Lv 1 1 pt. 6,221
  10. Avatar for carinita 80. carinita Lv 1 1 pt. 4,874

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.