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1518: Large Monomer Design

Closed since almost 8 years ago

Intermediate Overall Design

Summary

Created
May 07, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Beta Folders
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  10. Avatar for :) 10. :) 1 pt. 8,352
  1. Avatar for jobo0502 61. jobo0502 Lv 1 2 pts. 9,521
  2. Avatar for ourtown 62. ourtown Lv 1 2 pts. 9,419
  3. Avatar for Lord_c_nu 63. Lord_c_nu Lv 1 2 pts. 9,399
  4. Avatar for SouperGenious 64. SouperGenious Lv 1 2 pts. 9,219
  5. Avatar for mitarcher 65. mitarcher Lv 1 1 pt. 9,105
  6. Avatar for Superphosphate 66. Superphosphate Lv 1 1 pt. 9,079
  7. Avatar for Anamfija 67. Anamfija Lv 1 1 pt. 9,074
  8. Avatar for Shortbread 68. Shortbread Lv 1 1 pt. 8,948
  9. Avatar for gstelle 69. gstelle Lv 1 1 pt. 8,931
  10. Avatar for Arne Heessels 70. Arne Heessels Lv 1 1 pt. 8,918

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."