Placeholder image of a protein
Icon representing a puzzle

1524: Symmetric Dimer Design: Hydrogen Bond Networks

Closed since almost 8 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 22, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 18,320
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 73 pts. 18,009
  3. Avatar for Gargleblasters 3. Gargleblasters 52 pts. 18,004
  4. Avatar for Beta Folders 4. Beta Folders 36 pts. 17,963
  5. Avatar for Contenders 5. Contenders 24 pts. 17,759
  6. Avatar for Void Crushers 6. Void Crushers 16 pts. 17,420
  7. Avatar for Marvin's bunch 7. Marvin's bunch 10 pts. 17,412
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 6 pts. 16,778
  9. Avatar for HMT heritage 9. HMT heritage 4 pts. 16,304
  10. Avatar for Team South Africa 10. Team South Africa 2 pts. 11,770
  1. Avatar for ZeroLeak7
    1. ZeroLeak7 Lv 1
    100 pts. 18,320
  2. Avatar for mirp 2. mirp Lv 1 97 pts. 18,100
  3. Avatar for johnmitch 3. johnmitch Lv 1 93 pts. 18,007
  4. Avatar for Skippysk8s 4. Skippysk8s Lv 1 90 pts. 18,004
  5. Avatar for grogar7 5. grogar7 Lv 1 86 pts. 17,998
  6. Avatar for phi16 6. phi16 Lv 1 83 pts. 17,959
  7. Avatar for LociOiling 7. LociOiling Lv 1 80 pts. 17,957
  8. Avatar for JSmith48 8. JSmith48 Lv 1 77 pts. 17,927
  9. Avatar for actiasluna 9. actiasluna Lv 1 74 pts. 17,882
  10. Avatar for Galaxie 10. Galaxie Lv 1 71 pts. 17,800

Comments

bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 25 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 60 residues are buried in the core of the entire complex (including the interface between monomer units).

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to four hydrogen bonds may span the interface between chains. Networks must at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).

DoctorSockrates Lv 1

As of yet I haven't figured out any way to intuitively design networks from scratch quite yet. Reading about it, it seems straightforward on paper but kind of harder in practice. Has anyone made any videos on good strategies for these H-bond network puzzles or commentary on the process of building one?