Placeholder image of a protein
Icon representing a puzzle

1533: Symmetric Trimer Design: Hydrogen Bond Networks

Closed since over 7 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 12, 2018
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 18,396
  2. Avatar for Beta Folders 2. Beta Folders 77 pts. 18,164
  3. Avatar for Contenders 3. Contenders 58 pts. 17,951
  4. Avatar for Gargleblasters 4. Gargleblasters 43 pts. 17,940
  5. Avatar for Go Science 5. Go Science 31 pts. 17,861
  6. Avatar for Marvin's bunch 6. Marvin's bunch 22 pts. 17,298
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 15 pts. 17,073
  8. Avatar for Void Crushers 8. Void Crushers 11 pts. 17,038
  9. Avatar for Deleted group 9. Deleted group pts. 10,959
  10. Avatar for HMT heritage 10. HMT heritage 5 pts. 10,890
  1. Avatar for johnmitch
    1. johnmitch Lv 1
    100 pts. 18,593
  2. Avatar for Galaxie 2. Galaxie Lv 1 97 pts. 18,395
  3. Avatar for bertro 3. bertro Lv 1 93 pts. 18,164
  4. Avatar for LociOiling 4. LociOiling Lv 1 89 pts. 17,916
  5. Avatar for Skippysk8s 5. Skippysk8s Lv 1 85 pts. 17,775
  6. Avatar for retiredmichael 6. retiredmichael Lv 1 82 pts. 17,561
  7. Avatar for crpainter 7. crpainter Lv 1 79 pts. 17,512
  8. Avatar for spvincent 8. spvincent Lv 1 75 pts. 17,485
  9. Avatar for robgee 9. robgee Lv 1 72 pts. 17,423
  10. Avatar for pvc78 10. pvc78 Lv 1 69 pts. 17,371

Comments

bkoep Staff Lv 1

Core Existence: Monomer: Ensures that at least 24 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 72 residues are buried in the core of the entire complex (including the interface between monomer units). The threshold of "buriedness" between core and surface residues is more stringent than usual, so residues may have to be "extra buried" to be counted toward the core of the protein complex.

HBond Network: Rewards networks that comprise at least three hydrogen bonds involving core residues. Networks must be at least 75% satisfied (i.e. 75% of all polar atoms in a network must make a hydrogen bond).