Placeholder image of a protein
Icon representing a puzzle

1546: Extra Large Monomer Design

Closed since almost 8 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design

Summary

Created
July 09, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 10,274
  2. Avatar for Window Group 12. Window Group 1 pt. 4,222
  3. Avatar for Italiani Al Lavoro 13. Italiani Al Lavoro 1 pt. 2,053
  4. Avatar for test_group1 14. test_group1 1 pt. 952
  5. Avatar for Minions of TWIS 15. Minions of TWIS 1 pt. 0
  1. Avatar for Amsterdamaged 101. Amsterdamaged Lv 1 1 pt. 0
  2. Avatar for ReallyRatherDumb 102. ReallyRatherDumb Lv 1 1 pt. 0
  3. Avatar for WolfkiM 103. WolfkiM Lv 1 1 pt. 0
  4. Avatar for Jane Jiang 104. Jane Jiang Lv 1 1 pt. 0
  5. Avatar for joshmiller 105. joshmiller Lv 1 1 pt. 0
  6. Avatar for bkoep 106. bkoep Lv 1 1 pt. 0
  7. Avatar for gldisater 107. gldisater Lv 1 1 pt. 0
  8. Avatar for Simek 108. Simek Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.