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1546: Extra Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 09, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 10,274
  2. Avatar for Window Group 12. Window Group 1 pt. 4,222
  3. Avatar for Italiani Al Lavoro 13. Italiani Al Lavoro 1 pt. 2,053
  4. Avatar for test_group1 14. test_group1 1 pt. 952
  5. Avatar for Minions of TWIS 15. Minions of TWIS 1 pt. 0
  1. Avatar for fiendish_ghoul 11. fiendish_ghoul Lv 1 62 pts. 12,111
  2. Avatar for johnmitch 12. johnmitch Lv 1 59 pts. 12,082
  3. Avatar for Timo van der Laan 13. Timo van der Laan Lv 1 56 pts. 12,058
  4. Avatar for Bruno Kestemont 14. Bruno Kestemont Lv 1 53 pts. 12,018
  5. Avatar for hpaege 15. hpaege Lv 1 50 pts. 12,005
  6. Avatar for spvincent 16. spvincent Lv 1 47 pts. 11,943
  7. Avatar for crpainter 17. crpainter Lv 1 45 pts. 11,887
  8. Avatar for NinjaGreg 18. NinjaGreg Lv 1 43 pts. 11,821
  9. Avatar for stomjoh 19. stomjoh Lv 1 40 pts. 11,810
  10. Avatar for frood66 20. frood66 Lv 1 38 pts. 11,784

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.