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1546: Extra Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 09, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 10,274
  2. Avatar for Window Group 12. Window Group 1 pt. 4,222
  3. Avatar for Italiani Al Lavoro 13. Italiani Al Lavoro 1 pt. 2,053
  4. Avatar for test_group1 14. test_group1 1 pt. 952
  5. Avatar for Minions of TWIS 15. Minions of TWIS 1 pt. 0
  1. Avatar for cbwest 71. cbwest Lv 1 1 pt. 9,809
  2. Avatar for pfirth 72. pfirth Lv 1 1 pt. 9,767
  3. Avatar for gstelle 73. gstelle Lv 1 1 pt. 9,668
  4. Avatar for TastyMunchies 74. TastyMunchies Lv 1 1 pt. 9,502
  5. Avatar for Anamfija 75. Anamfija Lv 1 1 pt. 9,480
  6. Avatar for mitarcher 76. mitarcher Lv 1 1 pt. 9,441
  7. Avatar for spdenne 77. spdenne Lv 1 1 pt. 9,111
  8. Avatar for Gahmeir 78. Gahmeir Lv 1 1 pt. 8,891
  9. Avatar for Knoblerine 79. Knoblerine Lv 1 1 pt. 8,336
  10. Avatar for alyssajoyh 80. alyssajoyh Lv 1 1 pt. 8,307

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.