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1546: Extra Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 09, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,593
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 12,405
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 12,354
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  5. Avatar for Go Science 5. Go Science 19 pts. 12,018
  6. Avatar for Contenders 6. Contenders 11 pts. 11,943
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  9. Avatar for Stuyvesant Molecular Science 2017-18 9. Stuyvesant Molecular Science 2017-18 2 pts. 11,116
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 1 pt. 10,283
  1. Avatar for Might-o-chondria 41. Might-o-chondria Lv 1 10 pts. 11,116
  2. Avatar for joremen 42. joremen Lv 1 9 pts. 11,107
  3. Avatar for christioanchauvin 43. christioanchauvin Lv 1 9 pts. 11,095
  4. Avatar for phi16 44. phi16 Lv 1 8 pts. 11,086
  5. Avatar for dbuske 45. dbuske Lv 1 8 pts. 11,051
  6. Avatar for silent gene 46. silent gene Lv 1 7 pts. 10,869
  7. Avatar for weitzen 47. weitzen Lv 1 7 pts. 10,832
  8. Avatar for wozzarelli 48. wozzarelli Lv 1 6 pts. 10,814
  9. Avatar for jeff101 49. jeff101 Lv 1 6 pts. 10,738
  10. Avatar for Deleted player 50. Deleted player pts. 10,731

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.