Placeholder image of a protein
Icon representing a puzzle

1546: Extra Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
July 09, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,593
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 12,405
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 12,354
  4. Avatar for Void Crushers 4. Void Crushers 30 pts. 12,058
  5. Avatar for Go Science 5. Go Science 19 pts. 12,018
  6. Avatar for Contenders 6. Contenders 11 pts. 11,943
  7. Avatar for Marvin's bunch 7. Marvin's bunch 7 pts. 11,784
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 4 pts. 11,661
  9. Avatar for Stuyvesant Molecular Science 2017-18 9. Stuyvesant Molecular Science 2017-18 2 pts. 11,116
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 1 pt. 10,283
  1. Avatar for SouperGenious 61. SouperGenious Lv 1 2 pts. 10,359
  2. Avatar for rabamino12358 62. rabamino12358 Lv 1 2 pts. 10,344
  3. Avatar for JasperD 63. JasperD Lv 1 2 pts. 10,283
  4. Avatar for doctaven 64. doctaven Lv 1 2 pts. 10,274
  5. Avatar for diamonddays 65. diamonddays Lv 1 2 pts. 10,149
  6. Avatar for Arne Heessels 66. Arne Heessels Lv 1 1 pt. 10,126
  7. Avatar for smilingone 67. smilingone Lv 1 1 pt. 10,044
  8. Avatar for vinsi 68. vinsi Lv 1 1 pt. 10,028
  9. Avatar for hexidecimalhack 69. hexidecimalhack Lv 1 1 pt. 10,010
  10. Avatar for ourtown 70. ourtown Lv 1 1 pt. 10,008

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95, at a cost of 32 points per residue. Players may use up to 120 residues in total.