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1581: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Trinity Biology 11. Trinity Biology 1 pt. 10,269
  2. Avatar for freefolder 12. freefolder 1 pt. 9,702
  3. Avatar for Minions of TWIS 13. Minions of TWIS 1 pt. 0
  4. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 1 pt. 0
  1. Avatar for Glen B 21. Glen B Lv 1 36 pts. 12,106
  2. Avatar for MurloW 22. MurloW Lv 1 34 pts. 12,106
  3. Avatar for silent gene 23. silent gene Lv 1 33 pts. 12,095
  4. Avatar for tyler0911 24. tyler0911 Lv 1 31 pts. 12,070
  5. Avatar for Crossed Sticks 25. Crossed Sticks Lv 1 29 pts. 12,046
  6. Avatar for justjustin 26. justjustin Lv 1 27 pts. 11,999
  7. Avatar for jobo0502 27. jobo0502 Lv 1 26 pts. 11,964
  8. Avatar for christioanchauvin 28. christioanchauvin Lv 1 24 pts. 11,950
  9. Avatar for robgee 29. robgee Lv 1 23 pts. 11,940
  10. Avatar for spvincent 30. spvincent Lv 1 21 pts. 11,932

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.