Placeholder image of a protein
Icon representing a puzzle

1581: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,570
  2. Avatar for Contenders 2. Contenders 68 pts. 12,461
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 44 pts. 12,446
  4. Avatar for Beta Folders 4. Beta Folders 27 pts. 12,383
  5. Avatar for Marvin's bunch 5. Marvin's bunch 16 pts. 12,334
  6. Avatar for Go Science 6. Go Science 9 pts. 12,224
  7. Avatar for Void Crushers 7. Void Crushers 5 pts. 12,200
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 3 pts. 11,964
  9. Avatar for Russian team 9. Russian team 1 pt. 11,630
  10. Avatar for Deleted group 10. Deleted group pts. 10,413
  1. Avatar for Heyapple94 91. Heyapple94 Lv 1 1 pt. 6,315
  2. Avatar for helpmeplease 92. helpmeplease Lv 1 1 pt. 5,126
  3. Avatar for Alex_523 93. Alex_523 Lv 1 1 pt. 4,898
  4. Avatar for fialdarg 94. fialdarg Lv 1 1 pt. 4,898
  5. Avatar for abhxyz 95. abhxyz Lv 1 1 pt. 4,897
  6. Avatar for navneetsandhu 96. navneetsandhu Lv 1 1 pt. 4,343
  7. Avatar for ChemysteriAsh 97. ChemysteriAsh Lv 1 1 pt. 2,417
  8. Avatar for francesca_toledo 98. francesca_toledo Lv 1 1 pt. 0
  9. Avatar for tjonesster 99. tjonesster Lv 1 1 pt. 0
  10. Avatar for fitz77 100. fitz77 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.