Placeholder image of a protein
Icon representing a puzzle

1581: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,570
  2. Avatar for Contenders 2. Contenders 68 pts. 12,461
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 44 pts. 12,446
  4. Avatar for Beta Folders 4. Beta Folders 27 pts. 12,383
  5. Avatar for Marvin's bunch 5. Marvin's bunch 16 pts. 12,334
  6. Avatar for Go Science 6. Go Science 9 pts. 12,224
  7. Avatar for Void Crushers 7. Void Crushers 5 pts. 12,200
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 3 pts. 11,964
  9. Avatar for Russian team 9. Russian team 1 pt. 11,630
  10. Avatar for Deleted group 10. Deleted group pts. 10,413
  1. Avatar for 181818 51. 181818 Lv 1 5 pts. 11,459
  2. Avatar for asb4 52. asb4 Lv 1 5 pts. 11,413
  3. Avatar for cbwest 53. cbwest Lv 1 4 pts. 11,408
  4. Avatar for Merf 54. Merf Lv 1 4 pts. 11,380
  5. Avatar for alcor29 55. alcor29 Lv 1 4 pts. 11,357
  6. Avatar for MicElephant 56. MicElephant Lv 1 3 pts. 11,344
  7. Avatar for gurch 57. gurch Lv 1 3 pts. 11,343
  8. Avatar for sciencewalker 58. sciencewalker Lv 1 3 pts. 11,325
  9. Avatar for ClassicShyGuy 59. ClassicShyGuy Lv 1 3 pts. 11,320
  10. Avatar for Deleted player 60. Deleted player pts. 11,296

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.