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1589: Extra Small Monomer Design

Closed since over 7 years ago

Summary

Created: October 17, 2018
Expires: October 24, 2018 at 23:00 UTC
Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. HMT heritage 2 pts. 10,455
12. freefolder 1 pt. 10,322
13. Trinity Biology 1 pt. 9,757
14. Minions of TWIS 1 pt. 7,561
15. Eὕρηκα! Heureka! 1 pt. 7,470
16. QCNMIT 1 pt. 5,114
17. Window Group 1 pt. 0
18. FoldIt@Netherlands 1 pt. 0

51. fpc Lv 1 13 pts. 11,094
52. Marvelz Lv 1 13 pts. 11,093
53. asb4 Lv 1 12 pts. 11,053
54. Jesse Pinkman Lv 1 11 pts. 11,039
55. Hellcat6 Lv 1 11 pts. 11,035
56. manu8170 Lv 1 10 pts. 11,022
57. weitzen Lv 1 10 pts. 11,012
58. ClassicShyGuy Lv 1 9 pts. 10,987
59. dd-2 Lv 1 9 pts. 10,972
60. DNAgenius Lv 1 8 pts. 10,958

Comments

bkoep Staff Lv 1

October 17, 2018

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.