Placeholder image of a protein
Icon representing a puzzle

1589: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 17, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,117
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 74 pts. 12,090
  3. Avatar for Contenders 3. Contenders 54 pts. 12,020
  4. Avatar for Marvin's bunch 4. Marvin's bunch 38 pts. 11,962
  5. Avatar for Beta Folders 5. Beta Folders 27 pts. 11,956
  6. Avatar for Void Crushers 6. Void Crushers 18 pts. 11,928
  7. Avatar for Go Science 7. Go Science 12 pts. 11,813
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 8 pts. 11,646
  9. Avatar for Russian team 9. Russian team 5 pts. 11,244
  10. Avatar for Coastal Biochemistry 10. Coastal Biochemistry 3 pts. 10,800
  1. Avatar for fpc 51. fpc Lv 1 13 pts. 11,094
  2. Avatar for Marvelz 52. Marvelz Lv 1 13 pts. 11,093
  3. Avatar for asb4 53. asb4 Lv 1 12 pts. 11,053
  4. Avatar for Jesse Pinkman 54. Jesse Pinkman Lv 1 11 pts. 11,039
  5. Avatar for Hellcat6 55. Hellcat6 Lv 1 11 pts. 11,035
  6. Avatar for manu8170 56. manu8170 Lv 1 10 pts. 11,022
  7. Avatar for weitzen 57. weitzen Lv 1 10 pts. 11,012
  8. Avatar for ClassicShyGuy 58. ClassicShyGuy Lv 1 9 pts. 10,987
  9. Avatar for dd-2 59. dd-2 Lv 1 9 pts. 10,972
  10. Avatar for DNAgenius 60. DNAgenius Lv 1 8 pts. 10,958

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.