Placeholder image of a protein
Icon representing a puzzle

1589: Extra Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 17, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,117
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 74 pts. 12,090
  3. Avatar for Contenders 3. Contenders 54 pts. 12,020
  4. Avatar for Marvin's bunch 4. Marvin's bunch 38 pts. 11,962
  5. Avatar for Beta Folders 5. Beta Folders 27 pts. 11,956
  6. Avatar for Void Crushers 6. Void Crushers 18 pts. 11,928
  7. Avatar for Go Science 7. Go Science 12 pts. 11,813
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 8 pts. 11,646
  9. Avatar for Russian team 9. Russian team 5 pts. 11,244
  10. Avatar for Coastal Biochemistry 10. Coastal Biochemistry 3 pts. 10,800
  1. Avatar for rabamino12358 61. rabamino12358 Lv 1 8 pts. 10,927
  2. Avatar for mitarcher 62. mitarcher Lv 1 8 pts. 10,904
  3. Avatar for Deleted player 63. Deleted player pts. 10,898
  4. Avatar for TastyMunchies 64. TastyMunchies Lv 1 7 pts. 10,888
  5. Avatar for Deleted player 65. Deleted player pts. 10,883
  6. Avatar for elpirates 66. elpirates Lv 1 6 pts. 10,852
  7. Avatar for Deleted player 67. Deleted player pts. 10,847
  8. Avatar for SKSbell 68. SKSbell Lv 1 5 pts. 10,844
  9. Avatar for DoctorSockrates 69. DoctorSockrates Lv 1 5 pts. 10,837
  10. Avatar for dbuske 70. dbuske Lv 1 5 pts. 10,835

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +160)
Penalizes extra residues inserted beyond the starting 60, at a cost of 32 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.