1598: Cryo-EM Freestyle with Density

Closed since over 7 years ago

Summary

• Created: November 12, 2018
• Expires: November 27, 2018 at 14:00 UTC
• Max points: 100

Description

This protein is another part of the same protein complex with multiple subunits from Puzzle 1554 and Puzzle 1588, which has been the target of cryo-EM experiments. We are giving you an extended chain to start with, so good luck!

Top groups

• 11. Czech National Team 2 pts. 9,934
• 12. FoldIt@Netherlands 1 pt. 9,885
• 13. freefolder 1 pt. 9,530
• 14. cit 1 pt. 9,063
• 15. Trinity Biology 1 pt. 7,985
• 16. Team South Africa 1 pt. 4,015
• 17. Stuyvesant Molecular Science 2017-18 1 pt. 1,661
• 18. Deleted group pts. 0
• 19. DSN @ Home 1 pt. 0

Top soloists

• 1. grogar7 100 pts. 18,569
• 2. Susume 98 pts. 18,529
• 3. retiredmichael 95 pts. 18,509
• 4. LociOiling 92 pts. 18,452
• 5. Bruno Kestemont 89 pts. 18,377
• 6. fiendish_ghoul 87 pts. 18,327
• 7. drumpeter18yrs9yrs 84 pts. 18,307
• 8. bertro 82 pts. 18,286
• 9. guineapig 79 pts. 18,260
• 10. Anfinsen_slept_here 77 pts. 18,212

Comments

[jeff101]

I think this puzzle starts with all loops as
its secondary structure. Is that intentional?

[Bruno Kestemont]

LLLLLLLLEEEEEEELLLLLLLLEEEEEEEELLLEEEEEEEEEELLLLLEEEELLLLLLLLLEEEEEEELLLL
HHHHHHHHHHLLLLEEEEEEEEEEELLLLLEEEEEEELLEEEEEEEELLLLLLLLEEEEEEEEEEEELEEEEEEEL

copy-paste it in note 19 then run:
https://fold.it/portal/recipe/49556

(and run this recipe every time you want to recover it)

Source for prediction (it takes 30 minutes):
http://bioinf.cs.ucl.ac.uk/psipred/

[Bruno Kestemont]

However, PSIPRED prediction (bellow) is quite useful to help to fit into the density somewhere (but the density gives a quite different pattern after all)

[Vinara]

Thank you. Quick question for Foldit for Dummies: Where do I find note 19?

[jeff101]

In Puzzle 1598, if you are in the Original Interface using
the Rainbow color scheme, you can find Note 19 by Tabbing
on the blue end of the protein. A window called "Segment
Information" will appear for the segment you Tabbed on.
You can then use the left or right arrow key to move to
the "Segment Information" window for Isoleucine 19. At the
bottom of this window is a section called "Notes". You can
paste the desired secondary structure (listed above) in the
"Notes" section. The little trash can next to the "Notes"
section clears this section's contents.

[Vinara]

Thank you. :)

[toshiue]

…or you can use SS Edit 1.2 (recipe 102273)

[Bruno Kestemont]

Or AA Copy-Paste Compare