LociOiling Lv 1
This puzzle is huge, with 499 segments at the start.
It has three protein chains, plus three ligands.
So it probably sets a record for size and complexity.
The ligands are the single-atom kind, represented as black dots. They're a little hard to see with dark background. Switching to a light background makes them easy to spot.
Chain A is segments 1 to 193. It's "integrin alpha-V", an exact match for 6DJP and other structures in the PDB.
Chain B is segments 194 to 436. It's "integrin beta-3", a close but not exact match for 6AVU and others in the PDB. The matching portion of 6AVU has four additional segments not found in the Foldit version of the protein.
Chains A and B have locked backbone, but moveable sidechains. They have no mutable segments.
Chain C is the designable part, and is segments 437 to 496 at the start. It's 60 segments with the sequence "vtprgdwne" is the middle of isoleucine. The "vtprgdwne" part is has locked backbone and sidechains. It must be the "core RGD binding motif of the antagonist ligand" mentioned in the puzzle description.
The unlocked and mutable isoleucine sections are separated from the "vtprgdwne" part by two permanent cutpoints.
The three ligands are segments 497, 498, and 499 at the start. Each ligand shows as a dot in most views, but each reports three atoms. In the "Trace Line" view, the dots become triangles. The chemical nature of the ligands can't be determined in Foldit.
Just to break up all the threes, there are four disulfide bridges at the start:
34,54 68,81 264,271 319,360
Since the backbone is locked, these bridges will tend to stay in place. You can break them manually by dragging on the sidechains. There's no disulfide bridge objective, and no possibility of any additional disulfide bridges.
