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1669: Extra Small Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
April 30, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 55 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 2 pts. 11,439
  2. Avatar for DW 2020 12. DW 2020 1 pt. 11,366
  3. Avatar for HMT heritage 13. HMT heritage 1 pt. 11,278
  4. Avatar for Team South Africa 14. Team South Africa 1 pt. 11,210
  5. Avatar for freefolder 15. freefolder 1 pt. 11,066
  6. Avatar for MBB190 16. MBB190 1 pt. 10,239
  7. Avatar for I3L GANG 17. I3L GANG 1 pt. 10,184
  8. Avatar for Deleted group 18. Deleted group pts. 0
  1. Avatar for Steven Pletsch 41. Steven Pletsch Lv 1 20 pts. 11,564
  2. Avatar for fpc 42. fpc Lv 1 19 pts. 11,561
  3. Avatar for georg137 43. georg137 Lv 1 18 pts. 11,545
  4. Avatar for alcor29 44. alcor29 Lv 1 17 pts. 11,537
  5. Avatar for guineapig 45. guineapig Lv 1 16 pts. 11,527
  6. Avatar for ppp6 46. ppp6 Lv 1 15 pts. 11,526
  7. Avatar for Silvercraft 47. Silvercraft Lv 1 15 pts. 11,500
  8. Avatar for alwen 48. alwen Lv 1 14 pts. 11,483
  9. Avatar for Hellcat6 49. Hellcat6 Lv 1 13 pts. 11,481
  10. Avatar for Aminal88 50. Aminal88 Lv 1 13 pts. 11,468

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 60, at a cost of 55 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.