Placeholder image of a protein
Icon representing a puzzle

1669: Extra Small Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
April 30, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 55 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,222
  2. Avatar for Go Science 2. Go Science 74 pts. 12,139
  3. Avatar for Beta Folders 3. Beta Folders 54 pts. 12,130
  4. Avatar for Marvin's bunch 4. Marvin's bunch 38 pts. 12,061
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 27 pts. 12,004
  6. Avatar for Russian team 6. Russian team 18 pts. 11,985
  7. Avatar for Void Crushers 7. Void Crushers 12 pts. 11,983
  8. Avatar for Contenders 8. Contenders 8 pts. 11,948
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 5 pts. 11,862
  10. Avatar for Hold My Beer 10. Hold My Beer 3 pts. 11,564
  1. Avatar for phi16 31. phi16 Lv 1 31 pts. 11,736
  2. Avatar for Vinara 32. Vinara Lv 1 30 pts. 11,724
  3. Avatar for jobo0502 33. jobo0502 Lv 1 28 pts. 11,720
  4. Avatar for MicElephant 34. MicElephant Lv 1 27 pts. 11,694
  5. Avatar for christioanchauvin 35. christioanchauvin Lv 1 26 pts. 11,648
  6. Avatar for Merf 36. Merf Lv 1 25 pts. 11,643
  7. Avatar for stomjoh 37. stomjoh Lv 1 24 pts. 11,638
  8. Avatar for poiuytrewq987 38. poiuytrewq987 Lv 1 23 pts. 11,612
  9. Avatar for Blipperman 39. Blipperman Lv 1 22 pts. 11,607
  10. Avatar for smilingone 40. smilingone Lv 1 21 pts. 11,568

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 60, at a cost of 55 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.