Placeholder image of a protein
Icon representing a puzzle

1669: Extra Small Monomer Design

Closed since almost 7 years ago

Intermediate Overall Design

Summary

Created
April 30, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 55 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 12,222
  2. Avatar for Go Science 2. Go Science 74 pts. 12,139
  3. Avatar for Beta Folders 3. Beta Folders 54 pts. 12,130
  4. Avatar for Marvin's bunch 4. Marvin's bunch 38 pts. 12,061
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 27 pts. 12,004
  6. Avatar for Russian team 6. Russian team 18 pts. 11,985
  7. Avatar for Void Crushers 7. Void Crushers 12 pts. 11,983
  8. Avatar for Contenders 8. Contenders 8 pts. 11,948
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 5 pts. 11,862
  10. Avatar for Hold My Beer 10. Hold My Beer 3 pts. 11,564
  1. Avatar for aznarog 61. aznarog Lv 1 7 pts. 11,394
  2. Avatar for alwan2018 62. alwan2018 Lv 1 7 pts. 11,366
  3. Avatar for rezaefar 63. rezaefar Lv 1 6 pts. 11,360
  4. Avatar for Lyshi2018 64. Lyshi2018 Lv 1 6 pts. 11,326
  5. Avatar for O Seki To 65. O Seki To Lv 1 6 pts. 11,278
  6. Avatar for Arne Heessels 66. Arne Heessels Lv 1 5 pts. 11,274
  7. Avatar for junsuha 67. junsuha Lv 1 5 pts. 11,252
  8. Avatar for cbwest 68. cbwest Lv 1 5 pts. 11,237
  9. Avatar for manu8170 69. manu8170 Lv 1 4 pts. 11,233
  10. Avatar for Deleted player 70. Deleted player pts. 11,231

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 60, at a cost of 55 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.