Placeholder image of a protein
Icon representing a puzzle

1698: Medium Monomer Design

Closed since over 6 years ago

Intermediate Overall Design

Summary

Created
July 12, 2019
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 55 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 13,449
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 71 pts. 13,409
  3. Avatar for Gargleblasters 3. Gargleblasters 49 pts. 13,386
  4. Avatar for Go Science 4. Go Science 33 pts. 13,355
  5. Avatar for Void Crushers 5. Void Crushers 22 pts. 13,196
  6. Avatar for Contenders 6. Contenders 14 pts. 13,174
  7. Avatar for Russian team 7. Russian team 8 pts. 13,160
  8. Avatar for Marvin's bunch 8. Marvin's bunch 5 pts. 13,095
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 3 pts. 13,015
  10. Avatar for HMT heritage 10. HMT heritage 2 pts. 12,783
  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 13,447
  2. Avatar for dcrwheeler 2. dcrwheeler Lv 1 96 pts. 13,409
  3. Avatar for Deleted player 3. Deleted player pts. 13,398
  4. Avatar for anthion 4. anthion Lv 1 87 pts. 13,386
  5. Avatar for Phyx 5. Phyx Lv 1 83 pts. 13,350
  6. Avatar for actiasluna 6. actiasluna Lv 1 79 pts. 13,341
  7. Avatar for Skippysk8s 7. Skippysk8s Lv 1 75 pts. 13,320
  8. Avatar for johnmitch 8. johnmitch Lv 1 71 pts. 13,319
  9. Avatar for Galaxie 9. Galaxie Lv 1 68 pts. 13,308
  10. Avatar for NinjaGreg 10. NinjaGreg Lv 1 64 pts. 13,294

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices. Penalizes GLY, ALA in sheets.

Residue Count (max +825)
Penalizes extra residues inserted beyond the starting 75, at a cost of 55 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.