Placeholder image of a protein
Icon representing a puzzle

1722: Symmetric Trimer Design: 60 Residues

Closed since over 6 years ago

Intermediate Overall Design Symmetry

Summary

Created
August 28, 2019
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 17,108
  2. Avatar for Go Science 2. Go Science 68 pts. 17,056
  3. Avatar for Gargleblasters 3. Gargleblasters 44 pts. 17,024
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 27 pts. 16,939
  5. Avatar for Void Crushers 5. Void Crushers 16 pts. 16,805
  6. Avatar for Marvin's bunch 6. Marvin's bunch 9 pts. 16,583
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 5 pts. 16,555
  8. Avatar for Russian team 8. Russian team 3 pts. 16,443
  9. Avatar for Contenders 9. Contenders 1 pt. 16,426
  10. Avatar for HMT heritage 10. HMT heritage 1 pt. 15,593
  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 17,085
  2. Avatar for Phyx 2. Phyx Lv 1 95 pts. 17,056
  3. Avatar for silent gene 3. silent gene Lv 1 89 pts. 17,045
  4. Avatar for actiasluna 4. actiasluna Lv 1 84 pts. 17,024
  5. Avatar for retiredmichael 5. retiredmichael Lv 1 79 pts. 16,963
  6. Avatar for dcrwheeler 6. dcrwheeler Lv 1 74 pts. 16,939
  7. Avatar for grogar7 7. grogar7 Lv 1 70 pts. 16,922
  8. Avatar for hpaege 8. hpaege Lv 1 66 pts. 16,902
  9. Avatar for phi16 9. phi16 Lv 1 62 pts. 16,895
  10. Avatar for Galaxie 10. Galaxie Lv 1 58 pts. 16,891

Comments

bkoep Staff Lv 1

Core Existence: Monomer (max +3000)
Ensures that at least 16 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 60 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.