Placeholder image of a protein
Icon representing a puzzle

1781: Poly-Proline Helix Design: Round 6

Closed since about 6 years ago

Intermediate Overall Design

Summary

Created
January 02, 2020
Expires
Max points
100
Description

This is the sixth puzzle in the poly-proline helix design series! The starting structure is an 80 reside protein with a 5 residue helix, and all residues are mutable. However we have also increased the reference weight of proline from 16.4 to 50.0 to incentivize keeping proline part of the final design. There were some designs from the previous puzzle that satisfied a good fraction of the oxygens and nitrogens on the helix backbone, and we hope to see that continue. Hydrogen bonds are visible by selecting 'Show advanced GUI' in General Options in the Menu tab, and then selecting 'Show bonds (loop)' and 'Show bondable atoms' in the View tab.
Happy Folding!

Top groups

  1. Avatar for HMT heritage 11. HMT heritage 2 pts. 10,800
  2. Avatar for Team New Zealand 12. Team New Zealand 1 pt. 10,745
  3. Avatar for Trinity Biology 13. Trinity Biology 1 pt. 10,724
  4. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 1 pt. 10,691
  5. Avatar for foldeRNA 15. foldeRNA 1 pt. 10,564
  6. Avatar for Russian team 16. Russian team 1 pt. 10,342
  7. Avatar for uneRx 17. uneRx 1 pt. 4,852
  8. Avatar for Team Schleswig-Holstein 18. Team Schleswig-Holstein 1 pt. 536
  1. Avatar for ZeroLeak7
    1. ZeroLeak7 Lv 1
    100 pts. 12,235
  2. Avatar for pauldunn 2. pauldunn Lv 1 96 pts. 12,191
  3. Avatar for grogar7 3. grogar7 Lv 1 92 pts. 12,158
  4. Avatar for phi16 4. phi16 Lv 1 88 pts. 12,155
  5. Avatar for Bruno Kestemont 5. Bruno Kestemont Lv 1 84 pts. 12,059
  6. Avatar for alwen 6. alwen Lv 1 80 pts. 12,008
  7. Avatar for Galaxie 7. Galaxie Lv 1 77 pts. 11,984
  8. Avatar for jeff101 8. jeff101 Lv 1 73 pts. 11,940
  9. Avatar for silent gene 9. silent gene Lv 1 70 pts. 11,892
  10. Avatar for donuts554 10. donuts554 Lv 1 67 pts. 11,753

Comments

Deleted user

Residue Count (max +100)
Penalizes a residue count above 80 by 20 Foldit points per additional residue. The count is capped at 85.

Deleted user

Good question!

A poly-proline helix doesn't have to be made entirely of proline. Any set of residues that adopt the appropriate dihedral angles can be classified as a poly-proline helix. Proline is simply one of the few amino acids that can easily do so.