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1781: Poly-Proline Helix Design: Round 6

Closed since about 6 years ago

Intermediate Overall Design

Summary

Created
January 02, 2020
Expires
Max points
100
Description

This is the sixth puzzle in the poly-proline helix design series! The starting structure is an 80 reside protein with a 5 residue helix, and all residues are mutable. However we have also increased the reference weight of proline from 16.4 to 50.0 to incentivize keeping proline part of the final design. There were some designs from the previous puzzle that satisfied a good fraction of the oxygens and nitrogens on the helix backbone, and we hope to see that continue. Hydrogen bonds are visible by selecting 'Show advanced GUI' in General Options in the Menu tab, and then selecting 'Show bonds (loop)' and 'Show bondable atoms' in the View tab.
Happy Folding!

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Comments

Deleted user

Residue Count (max +100)
Penalizes a residue count above 80 by 20 Foldit points per additional residue. The count is capped at 85.

Deleted user

Good question!

A poly-proline helix doesn't have to be made entirely of proline. Any set of residues that adopt the appropriate dihedral angles can be classified as a poly-proline helix. Proline is simply one of the few amino acids that can easily do so.