1938: Symmetric Tetramer Design: H-bond Networks

Closed since about 5 years ago

Summary

• Created: January 01, 2021
• Expires: January 08, 2021 at 23:00 UTC
• Max points: 100

Description

Design a symmetric protein tetramer, with 4 identical chains that assemble together! The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.

Top groups

• 1. Gargleblasters 100 pts. 24,545
• 2. Go Science 70 pts. 24,534
• 3. Contenders 47 pts. 23,439
• 4. Beta Folders 30 pts. 22,955
• 5. Anthropic Dreams 19 pts. 21,882
• 6. Marvin's bunch 11 pts. 19,756
• 7. L'Alliance Francophone 7 pts. 19,755
• 8. BOINC@Poland 4 pts. 19,675
• 9. Void Crushers 2 pts. 19,095
• 10. Australia 1 pt. 17,809

Top soloists

• 1. Enzyme 100 pts. 24,506
• 2. ichwilldiesennamen 96 pts. 24,489
• 3. ZeroLeak7 91 pts. 24,167
• 4. BootsMcGraw 87 pts. 23,381
• 5. LociOiling 83 pts. 22,955
• 6. g_b 79 pts. 22,890
• 7. silent gene 75 pts. 22,576
• 8. spvincent 71 pts. 22,465
• 9. fiendish_ghoul 68 pts. 22,077
• 10. OWM3 64 pts. 22,018

Comments

[bkoep]

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2800)
Ensures that at least 28 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +2400)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

[grogar7]

A little late to be reporting this, perhaps, but Puzzle 1938 has been crashing regularly. This happens when scripts are running, and has been reported by other team mates as well. Tvdl Filter Mutate Combo 1.0.0 and Acid Tweeker are among the culprits. Unfortunately, I have not been able to catch this as it happens.
I start a script. It seems to be running normally. I walk away. I come back 15 minutes later and the client has disappeared.
Very frustrating!

[bkoep]

The next time Foldit crashes, and before you restart Foldit, it would help if you could check the log.txt file for any error messages. Or you could open a new Feedback issue and just load the log.txt file and I'll be happy to take a look at it.

Of course, if you learn any more details about when the crash occurs, that will also help!