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Successful Binder Design Sandbox

Closed since almost 4 years ago

Intermediate

Summary

Created
April 05, 2022
Expires
Max points
100
Description

This sandbox puzzle features three successful protein binders designed by scientists in this recent research paper. There are three starting structures, showing designed binders for CD3-delta, FGF receptor 2, and IGF1 receptor. Reset the puzzle to cycle through the different starting structures.

For more, check out Foldit Lab Report #31 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 12,659
  2. Avatar for Go Science 2. Go Science 60 pts. 12,494
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  6. Avatar for Team China 6. Team China 4 pts. 12,034
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  8. Avatar for Haykapnayan 8. Haykapnayan 1 pt. 11,998
  9. Avatar for Gargleblasters 9. Gargleblasters 1 pt. 11,998
  10. Avatar for Contenders 10. Contenders 1 pt. 11,998
  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 12,659
  2. Avatar for zippyc137 2. zippyc137 Lv 1 91 pts. 12,608
  3. Avatar for Aubade01 3. Aubade01 Lv 1 82 pts. 12,572
  4. Avatar for WBarme1234 4. WBarme1234 Lv 1 73 pts. 12,505
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  7. Avatar for phi16 7. phi16 Lv 1 53 pts. 12,386
  8. Avatar for akaaka 8. akaaka Lv 1 47 pts. 12,293
  9. Avatar for zbp 9. zbp Lv 1 42 pts. 12,279
  10. Avatar for rinze 10. rinze Lv 1 37 pts. 12,257

Comments

LociOiling Lv 1

When I try to load a pose from the previous version of this puzzle, I get the error:

Error in sequence mapping size. Attempted to load pose of size 163 into a puzzle of size 124.

bkoep Staff Lv 1

Hmm, this look like a bug with multi-start puzzles, and unfortunately I don't have a solution for it right now. Your old solutions may be "trapped" in the expired puzzle.

If you want to continue working with those solutions, you will have to do so in the expired puzzle. Beware that the expired puzzle is not fully compatible with a forthcoming update, and Foldit may crash if you try to share solutions between devprev and main clients.

toshiue Lv 1

Has the scoreboard been halted then? I'm at 12,558 and still showing 11,995 on the scoreboard.

bkoep Staff Lv 1

That is strange. You're playing online? I wonder if your client is having trouble reaching the server. You may try saving your solution and restarting Foldit.

Also worth double checking that you are not playing the expired version of this puzzle. Yesterday we closed and reposted the original Successful Binder Design Sandbox puzzle in preparation of a software update.

toshiue Lv 1

Saved and closed both solo clients. Reloaded puzzle and got an error message on both clients when I reloaded my saved scores.
"Error in sequence mapping size. Attempted to load pose 203 into a puzzle of size 124."
Frozen. Won't load any.

toshiue Lv 1

as Loci and Aubade01 had. Started over, that was an equally bad mess. Quitting the puzzle.