Placeholder image of a protein
Icon representing a puzzle

571: Tissue Regeneration Design Puzzle

Closed since over 13 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 9,570
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 84 pts. 9,569
  3. Avatar for Contenders 3. Contenders 70 pts. 9,560
  4. Avatar for foldeRNA 4. foldeRNA 58 pts. 9,545
  5. Avatar for HMT heritage 5. HMT heritage 48 pts. 9,544
  6. Avatar for Void Crushers 6. Void Crushers 39 pts. 9,543
  7. Avatar for FoldIt@Netherlands 7. FoldIt@Netherlands 32 pts. 9,537
  8. Avatar for Deleted group 8. Deleted group pts. 9,531
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 20 pts. 9,527
  10. Avatar for Deleted group 10. Deleted group pts. 9,511
  1. Avatar for jermainiac 21. jermainiac Lv 1 74 pts. 9,540
  2. Avatar for Rav3n_pl 22. Rav3n_pl Lv 1 73 pts. 9,540
  3. Avatar for Timo van der Laan 23. Timo van der Laan Lv 1 72 pts. 9,538
  4. Avatar for Hanto_FZ140E_4G 24. Hanto_FZ140E_4G Lv 1 71 pts. 9,538
  5. Avatar for ViJay7019 25. ViJay7019 Lv 1 70 pts. 9,537
  6. Avatar for lamoille 26. lamoille Lv 1 69 pts. 9,537
  7. Avatar for martinzblavy 27. martinzblavy Lv 1 68 pts. 9,536
  8. Avatar for johnmitch 28. johnmitch Lv 1 67 pts. 9,536
  9. Avatar for c1261015 29. c1261015 Lv 1 66 pts. 9,535
  10. Avatar for smilingone 30. smilingone Lv 1 65 pts. 9,535

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.