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571: Tissue Regeneration Design Puzzle

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 9,570
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 84 pts. 9,569
  3. Avatar for Contenders 3. Contenders 70 pts. 9,560
  4. Avatar for foldeRNA 4. foldeRNA 58 pts. 9,545
  5. Avatar for HMT heritage 5. HMT heritage 48 pts. 9,544
  6. Avatar for Void Crushers 6. Void Crushers 39 pts. 9,543
  7. Avatar for FoldIt@Netherlands 7. FoldIt@Netherlands 32 pts. 9,537
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  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 20 pts. 9,527
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  1. Avatar for mottiger 51. mottiger Lv 1 46 pts. 9,523
  2. Avatar for Madde 52. Madde Lv 1 45 pts. 9,522
  3. Avatar for Susume 53. Susume Lv 1 44 pts. 9,521
  4. Avatar for hpaege 54. hpaege Lv 1 44 pts. 9,521
  5. Avatar for stg123123 55. stg123123 Lv 1 43 pts. 9,521
  6. Avatar for jecauril 56. jecauril Lv 1 42 pts. 9,519
  7. Avatar for meatexplosion 57. meatexplosion Lv 1 41 pts. 9,518
  8. Avatar for LavenderSky 58. LavenderSky Lv 1 41 pts. 9,518
  9. Avatar for goastano 59. goastano Lv 1 40 pts. 9,516
  10. Avatar for Ch Garnier 60. Ch Garnier Lv 1 39 pts. 9,515

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.