Placeholder image of a protein
Icon representing a puzzle

676: 76 Residue Monomer Freestyle

Closed since about 13 years ago

Beginner Overall Design

Summary

Created
February 14, 2013
Expires
Max points
100
Description

We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer.

There are four filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The 1st LayerScore filter ensures the number of residues in the core is between 30% and 70%. The 2nd LayerScore filter ensures the number of residues on the surface is between 30% and 70%. The 3rd LayerScore filter ensures the number of boundary (residues between the core and surface) residues is below 70%. We hope these filters will help you design proteins that the scientists will be able to create in the lab.

Top groups

  1. Avatar for Void Crushers
    1. Void Crushers
    100 pts. 11,399
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 86 pts. 11,388
  3. Avatar for Contenders 3. Contenders 74 pts. 11,339
  4. Avatar for Beta Folders 4. Beta Folders 63 pts. 11,288
  5. Avatar for SETI.Germany 5. SETI.Germany 53 pts. 11,273
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 44 pts. 11,207
  7. Avatar for Go Science 7. Go Science 37 pts. 11,130
  8. Avatar for Gargleblasters 8. Gargleblasters 31 pts. 11,110
  9. Avatar for HMT heritage 9. HMT heritage 25 pts. 11,109
  10. Avatar for Deleted group 10. Deleted group pts. 11,076
  1. Avatar for Timo van der Laan
    1. Timo van der Laan Lv 1
    100 pts. 11,399
  2. Avatar for johnmitch 2. johnmitch Lv 1 99 pts. 11,349
  3. Avatar for karstenw 3. karstenw Lv 1 98 pts. 11,344
  4. Avatar for martinzblavy 4. martinzblavy Lv 1 96 pts. 11,339
  5. Avatar for stg123123 5. stg123123 Lv 1 95 pts. 11,288
  6. Avatar for jakbinimbol 6. jakbinimbol Lv 1 94 pts. 11,283
  7. Avatar for Susanne 7. Susanne Lv 1 92 pts. 11,273
  8. Avatar for gmn 8. gmn Lv 1 91 pts. 11,257
  9. Avatar for justjustin 9. justjustin Lv 1 90 pts. 11,256
  10. Avatar for mimi 10. mimi Lv 1 88 pts. 11,226

Comments

tamirh Lv 1

The Layer Score filter ensures the proteins will fold up into desirable and realistic shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.