Placeholder image of a protein
Icon representing a puzzle

676: 76 Residue Monomer Freestyle

Closed since about 13 years ago

Beginner Beginner Overall Overall Design Design

Summary

Created
February 14, 2013
Expires
Max points
100
Description

We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer.

There are four filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The 1st LayerScore filter ensures the number of residues in the core is between 30% and 70%. The 2nd LayerScore filter ensures the number of residues on the surface is between 30% and 70%. The 3rd LayerScore filter ensures the number of boundary (residues between the core and surface) residues is below 70%. We hope these filters will help you design proteins that the scientists will be able to create in the lab.

Top groups

  1. Avatar for FoldIt@Netherlands 11. FoldIt@Netherlands 17 pts. 11,050
  2. Avatar for Russian team 12. Russian team 14 pts. 10,966
  3. Avatar for foldeRNA 13. foldeRNA 11 pts. 10,941
  4. Avatar for Team Schleswig-Holstein 14. Team Schleswig-Holstein 9 pts. 10,858
  5. Avatar for Richard Dawkins Foundation 15. Richard Dawkins Foundation 7 pts. 10,585
  6. Avatar for Piratenpartei Deutschland 16. Piratenpartei Deutschland 5 pts. 10,564
  7. Avatar for Brony@Home 17. Brony@Home 4 pts. 10,562
  8. Avatar for Deleted group 18. Deleted group pts. 10,204
  9. Avatar for Cannabis Crew 19. Cannabis Crew 2 pts. 9,939
  10. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 2 pts. 7,330
  1. Avatar for kokosune 181. kokosune Lv 1 3 pts. 8,684
  2. Avatar for martinf 182. martinf Lv 1 3 pts. 8,678
  3. Avatar for stv139 183. stv139 Lv 1 3 pts. 8,653
  4. Avatar for joaniegirl 184. joaniegirl Lv 1 3 pts. 8,616
  5. Avatar for alphahelix10 185. alphahelix10 Lv 1 3 pts. 8,612
  6. Avatar for Jobriq 186. Jobriq Lv 1 3 pts. 8,526
  7. Avatar for multaq 187. multaq Lv 1 3 pts. 8,451
  8. Avatar for rinze 188. rinze Lv 1 3 pts. 8,398
  9. Avatar for bob1928 189. bob1928 Lv 1 3 pts. 8,350
  10. Avatar for hberlioz3 190. hberlioz3 Lv 1 3 pts. 8,345

Comments

tamirh Lv 1

The Layer Score filter ensures the proteins will fold up into desirable and realistic shapes. It will categorize each backbone residue as either 'core', 'surface', or 'boundary'. If you think of the protein as being suspended in a liquid, the 'surface' residues are those most exposed to the liquid. Subsequently, the 'core' residues are those that are most protected and the 'boundary' residues are the ones that lie between the 'core' and the 'surface'. Most residues are categorized as either 'core' or 'surface'.