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856: Trimer Interface Redesign: Round 3

Closed since about 12 years ago

Intermediate Overall Design Symmetry

Summary

Created
March 07, 2014
Expires
Max points
100
Description

This is the third round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. Due to some bugs apparent in previous rounds of this puzzle, players will NOT be able to load in solutions from Puzzles 851 or 852.

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Comments

wisky Lv 1

Just wondering how you guys went about "increasing tolerance for buried polar residues." Does this have something to with the "hiding" subscore for polar residues?

bkoep Staff Lv 1

There's a score term (represented by the 'Hiding' subscore) in these puzzles that inflicts a penalty when a polar residue is in close proximity to many other residues (i.e. in the core of the protein).

This relative weight of this score term is reduced in each iteration of the puzzle.