Placeholder image of a protein
Icon representing a puzzle

856: Trimer Interface Redesign: Round 3

Closed since about 12 years ago

Intermediate Overall Design Symmetry

Summary

Created
March 07, 2014
Expires
Max points
100
Description

This is the third round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. Due to some bugs apparent in previous rounds of this puzzle, players will NOT be able to load in solutions from Puzzles 851 or 852.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 15,040
  2. Avatar for Beta Folders 2. Beta Folders 82 pts. 14,916
  3. Avatar for Void Crushers 3. Void Crushers 66 pts. 14,865
  4. Avatar for Contenders 4. Contenders 53 pts. 14,720
  5. Avatar for Russian team 5. Russian team 42 pts. 14,697
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 33 pts. 14,687
  7. Avatar for HMT heritage 7. HMT heritage 26 pts. 14,608
  8. Avatar for Go Science 8. Go Science 20 pts. 14,556
  9. Avatar for Deleted group 9. Deleted group pts. 14,528
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 11 pts. 14,463
  1. Avatar for karstenw
    1. karstenw Lv 1
    100 pts. 15,040
  2. Avatar for matosfran 2. matosfran Lv 1 98 pts. 14,916
  3. Avatar for bertro 3. bertro Lv 1 95 pts. 14,891
  4. Avatar for caglar 4. caglar Lv 1 93 pts. 14,884
  5. Avatar for hansvandenhof 5. hansvandenhof Lv 1 90 pts. 14,881
  6. Avatar for Timo van der Laan 6. Timo van der Laan Lv 1 88 pts. 14,865
  7. Avatar for Galaxie 7. Galaxie Lv 1 86 pts. 14,757
  8. Avatar for g_b 8. g_b Lv 1 83 pts. 14,718
  9. Avatar for gmn 9. gmn Lv 1 81 pts. 14,698
  10. Avatar for auntdeen 10. auntdeen Lv 1 79 pts. 14,688

Comments

wisky Lv 1

Just wondering how you guys went about "increasing tolerance for buried polar residues." Does this have something to with the "hiding" subscore for polar residues?

bkoep Staff Lv 1

There's a score term (represented by the 'Hiding' subscore) in these puzzles that inflicts a penalty when a polar residue is in close proximity to many other residues (i.e. in the core of the protein).

This relative weight of this score term is reduced in each iteration of the puzzle.