937: 65 Residue Monomer Design

Closed since over 11 years ago

Summary

• Created: July 10, 2014
• Expires: July 17, 2014 at 23:00 UTC
• Max points: 100

Description

This design puzzle introduces a new filter! The Secondary Structure filter counts the number of residues in helices or sheets by recognizing hydrogen-bonding patterns. Players will receive a 500 point bonus if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. There are 3 additional filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 20% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Beta Folders 100 pts. 10,081
• 2. Anthropic Dreams 83 pts. 10,050
• 3. Void Crushers 68 pts. 9,961
• 4. Go Science 55 pts. 9,940
• 5. HMT heritage 44 pts. 9,926
• 6. Contenders 35 pts. 9,905
• 7. SETI.Germany 27 pts. 9,814
• 8. L'Alliance Francophone 21 pts. 9,723
• 9. Gargleblasters 16 pts. 9,710
• 10. Italiani Al Lavoro 12 pts. 9,701

Top soloists

• 11. wisky 79 pts. 9,904
• 12. spvincent 77 pts. 9,899
• 13. viosca 76 pts. 9,871
• 14. Galaxie 74 pts. 9,870
• 15. BootsMcGraw 72 pts. 9,842
• 16. johnmitch 70 pts. 9,833
• 17. Bautho 68 pts. 9,814
• 18. Susume 67 pts. 9,787
• 19. Vredeman 65 pts. 9,771
• 20. grogar7 63 pts. 9,762

Comments

[BootsMcGraw]

After years of devoted sacrifice on the Altar of the Aminos, the FoldIt gods have finally heard my prayer!

The megahelix was an evil, evil construction, spawned from the depths of the abyss, created to supplant the folding scores of realistic designs garnered by the Faithful and send them to the bottom of the top fifty.

But no more! From the heavens came The Secondary Structure Filter, and it divinely kicked the megahelix back into the bowels of Hell, where it belongs.

I bow in honor and reverence to the new Folding Design World Order.

[wisky]

One, two! One, two! and through and through
The vorpal blade went snicker-snack!
He left it dead, and with its head
He went galumphing back.

"And hast thou slain the Jabberwock?
Come to my arms, my beamish boy!
O frabjous day! Callooh! Callay!"
He chortled in his joy.

'Twas brillig, and the slithy toves
Did gyre and gimble in the wabe;
All mimsy were the borogoves,
And the mome raths outgrabe.

[Vredeman]

Megahelix thou hast been
High scoring and obscene
By folders thou wast deemed
No friend but a fiend