Placeholder image of a protein
Icon representing a puzzle

969: 75 Residue Monomer Design: Folded Sheets

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
August 14, 2014
Expires
Max points
100
Description

In this design puzzle, players will receive a 500 point bonus from the Secondary Structure filter if at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets. There are 3 additional filters: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,181
  2. Avatar for Go Science 2. Go Science 83 pts. 10,072
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 69 pts. 10,007
  4. Avatar for Contenders 4. Contenders 56 pts. 9,924
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 45 pts. 9,874
  6. Avatar for Void Crushers 6. Void Crushers 36 pts. 9,871
  7. Avatar for Gargleblasters 7. Gargleblasters 29 pts. 9,816
  8. Avatar for Deleted group 8. Deleted group pts. 9,692
  9. Avatar for SETI.Germany 9. SETI.Germany 18 pts. 9,531
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 14 pts. 9,445
  1. Avatar for mirp
    1. mirp Lv 1
    100 pts. 10,068
  2. Avatar for wisky 2. wisky Lv 1 99 pts. 9,976
  3. Avatar for Museka 3. Museka Lv 1 97 pts. 9,874
  4. Avatar for spdenne 4. spdenne Lv 1 96 pts. 9,871
  5. Avatar for nemo7731 5. nemo7731 Lv 1 95 pts. 9,843
  6. Avatar for MurloW 6. MurloW Lv 1 93 pts. 9,812
  7. Avatar for retiredmichael 7. retiredmichael Lv 1 92 pts. 9,798
  8. Avatar for spvincent 8. spvincent Lv 1 90 pts. 9,796
  9. Avatar for Galaxie 9. Galaxie Lv 1 89 pts. 9,785
  10. Avatar for drumpeter18yrs9yrs 10. drumpeter18yrs9yrs Lv 1 87 pts. 9,692

Comments

BootsMcGraw Lv 1

I have thirty-eight segments in the sheet configuration, which is more than fifty percent, yet I am still penalized thousands of points. Please review your scoring algorithms.