Foldit Puzzles

1727: Revisiting Puzzle 69: Scorpion Toxin

This is a throwback puzzle to the early days of Foldit. This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 55. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1728: IL-7R Binder Redesign: Round 12

Design a protein that binds IL-7R!

1725: Symmetric Trimer Design: 80 Residues

This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1726: IL-7R Binder Redesign: Round 11

Design a protein that binds IL-7R!

1724: Revisiting Puzzle 68: Bos Taurus

This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1723: IL-7R Binder Redesign: Round 10

Note: This puzzle was closed early, due to an error in the puzzle setup that allowed free movement of the IL-7R binding helices. The puzzle has been reposted as Puzzle 1723b.

1723b: IL-7R Binder Redesign: Round 10

Note: This puzzle replaces the original Puzzle 1723, which was incorrectly set up to allow free movement of the binding helices. Unfortunately, players will not be allowed to load solutions from the original Puzzle 1723.

1722: Symmetric Trimer Design: 60 Residues

This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1720: Revisiting Puzzle 67: Integrase

This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1721: IL-7R Binder Redesign: Round 9

Design a protein that binds IL-7R!