Foldit Puzzles

1240: Unsolved De-novo Freestyle 80: Predicted Contacts

Note: This puzzle was closed early due to an error in sharing settings. It has been reposted as Puzzle 1240b. Players may load solutions from this puzzle into the reposted Puzzle 1240b.

1240b: Unsolved De-novo Freestyle 80: Predicted Contacts

Note: This puzzle is a repost of Puzzle 1240, which was closed early due to an error in sharing settings. In this puzzle, players should be able to correctly load in solutions from Puzzle 1237 and the original Puzzle 1240.

1239: 65 Residue Monomer Design: Residue Count Filter

In this design puzzle, the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 65 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1238: Revisiting Puzzle 52: Bacteria Energy

This is a throwback puzzle to the early days of Foldit. This protein is part of a metabolic pathway used by bacteria to harvest energy from sugars. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1237: Unsolved De-novo Freestyle 80

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1236: 80 Residue Monomer Design: Residue Count Filter

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 80 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1235: Revisiting Puzzle 165: Rosetta Decoy 15

This is a throwback puzzle to the early days of Foldit. This protein helps to maintain the reduction potential of the cell. The protein contains four cysteine residues, but only two oxidize to form a single disulfide bond. The starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1234: Unsolved De-novo Freestyle 79: Predicted Contacts

This is a follow-up puzzle for Puzzle 1231, now with Predicted Contacts to help guide your folding! See the blog for information on using the contact map. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of green, with brighter green contacts indicating stronger predictions. Players will be able to load in manual saves from Puzzle 1231 and use them as a starting point here.

1233: 90 Residue Monomer Design: Residue Count Filter

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 90 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1232: Revisiting Puzzle 157: Rosetta Decoy 14

This is a throwback puzzle to the early days of Foldit. This domain is part of a T-cell receptor that recognizes pathogens in the body; the starting structure is a Rosetta model. This protein contains two cysteine residues which oxidize to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.