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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 9,516
  2. Avatar for Beta Folders 2. Beta Folders 84 pts. 9,499
  3. Avatar for Go Science 3. Go Science 70 pts. 9,494
  4. Avatar for Deleted group 4. Deleted group pts. 9,491
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 48 pts. 9,484
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 39 pts. 9,450
  7. Avatar for Void Crushers 7. Void Crushers 32 pts. 9,430
  8. Avatar for Contenders 8. Contenders 26 pts. 9,423
  9. Avatar for SETI.Germany 9. SETI.Germany 20 pts. 9,333
  10. Avatar for Russian team 10. Russian team 16 pts. 9,302
  1. Avatar for benjy33 11. benjy33 Lv 1 81 pts. 9,463
  2. Avatar for stomjoh 12. stomjoh Lv 1 79 pts. 9,463
  3. Avatar for Bruno Kestemont 13. Bruno Kestemont Lv 1 78 pts. 9,458
  4. Avatar for Blipperman 14. Blipperman Lv 1 76 pts. 9,457
  5. Avatar for grogar7 15. grogar7 Lv 1 74 pts. 9,456
  6. Avatar for mirp 16. mirp Lv 1 73 pts. 9,454
  7. Avatar for Zuqq 17. Zuqq Lv 1 71 pts. 9,451
  8. Avatar for nicobul 18. nicobul Lv 1 69 pts. 9,450
  9. Avatar for karstenw 19. karstenw Lv 1 68 pts. 9,449
  10. Avatar for Crossed Sticks 20. Crossed Sticks Lv 1 66 pts. 9,447

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.