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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 9,516
  2. Avatar for Beta Folders 2. Beta Folders 84 pts. 9,499
  3. Avatar for Go Science 3. Go Science 70 pts. 9,494
  4. Avatar for Deleted group 4. Deleted group pts. 9,491
  5. Avatar for Anthropic Dreams 5. Anthropic Dreams 48 pts. 9,484
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 39 pts. 9,450
  7. Avatar for Void Crushers 7. Void Crushers 32 pts. 9,430
  8. Avatar for Contenders 8. Contenders 26 pts. 9,423
  9. Avatar for SETI.Germany 9. SETI.Germany 20 pts. 9,333
  10. Avatar for Russian team 10. Russian team 16 pts. 9,302
  1. Avatar for Bletchley Park 31. Bletchley Park Lv 1 51 pts. 9,423
  2. Avatar for Museka 32. Museka Lv 1 50 pts. 9,419
  3. Avatar for jobo0502 33. jobo0502 Lv 1 49 pts. 9,418
  4. Avatar for hpaege 34. hpaege Lv 1 48 pts. 9,414
  5. Avatar for spvincent 35. spvincent Lv 1 46 pts. 9,410
  6. Avatar for pvc78 36. pvc78 Lv 1 45 pts. 9,403
  7. Avatar for spmm 37. spmm Lv 1 44 pts. 9,402
  8. Avatar for gurra66 38. gurra66 Lv 1 43 pts. 9,401
  9. Avatar for Already taken 39. Already taken Lv 1 42 pts. 9,401
  10. Avatar for gitwut 40. gitwut Lv 1 41 pts. 9,400

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.