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1002: 22 Residue Peptide Design

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
October 20, 2014
Expires
Max points
100
Description

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Gargleblasters
    100 pts. 9,516
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  3. Avatar for smholst 23. smholst Lv 1 62 pts. 9,439
  4. Avatar for BitSpawn 24. BitSpawn Lv 1 60 pts. 9,435
  5. Avatar for Galaxie 25. Galaxie Lv 1 59 pts. 9,433
  6. Avatar for pauldunn 26. pauldunn Lv 1 58 pts. 9,431
  7. Avatar for MurloW 27. MurloW Lv 1 56 pts. 9,430
  8. Avatar for Mike Cassidy 28. Mike Cassidy Lv 1 55 pts. 9,430
  9. Avatar for Timo van der Laan 29. Timo van der Laan Lv 1 54 pts. 9,429
  10. Avatar for silverberg 30. silverberg Lv 1 52 pts. 9,428

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 10% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Disulfide Filter: Yields a bonus of up to 1000 points for 2 or 3 disulfide bonds. More than 3 disulfides will incur penalties.