1169: 75 Residue Monomer Design

Closed since about 10 years ago

Summary

• Created: December 11, 2015
• Expires: December 18, 2015 at 23:00 UTC
• Max points: 100

Description

This is a basic 75 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 10,502
• 2. Gargleblasters 77 pts. 10,495
• 3. Go Science 58 pts. 10,491
• 4. Beta Folders 43 pts. 10,488
• 5. Contenders 31 pts. 10,460
• 6. L'Alliance Francophone 22 pts. 10,396
• 7. Void Crushers 15 pts. 10,378
• 8. Deleted group pts. 10,196
• 9. HMT heritage 7 pts. 10,150
• 10. xkcd 5 pts. 10,040

Top soloists

• 151. smarthuman 1 pt. 7,213
• 152. jchack10 1 pt. 7,184
• 153. SaDeB2015 1 pt. 7,100
• 154. Akatosh 1 pt. 7,100
• 155. marie.c 1 pt. 7,099
• 156. blueispydoesgaming 1 pt. 7,098
• 157. LukaTheWizard 1 pt. 7,098
• 158. MaartenDesnouck 1 pt. 7,087
• 159. oceanic1986 1 pt. 6,657
• 160. tela 1 pt. 6,436

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.