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1373: Extra Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
May 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,953
  2. Avatar for Gargleblasters 2. Gargleblasters 78 pts. 10,902
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  1. Avatar for manu8170 91. manu8170 Lv 1 1 pt. 7,483
  2. Avatar for Dan01924 92. Dan01924 Lv 1 1 pt. 7,460
  3. Avatar for SKSbell 93. SKSbell Lv 1 1 pt. 7,439
  4. Avatar for andrelo 94. andrelo Lv 1 1 pt. 7,376
  5. Avatar for martinf 95. martinf Lv 1 1 pt. 7,338
  6. Avatar for dbuske 96. dbuske Lv 1 1 pt. 7,290
  7. Avatar for Deleted player 97. Deleted player pts. 7,268
  8. Avatar for fpc 98. fpc Lv 1 1 pt. 7,261
  9. Avatar for Superphosphate 99. Superphosphate Lv 1 1 pt. 7,217
  10. Avatar for WBarme1234 100. WBarme1234 Lv 1 1 pt. 7,142

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."