Placeholder image of a protein
Icon representing a puzzle

1373: Extra Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
May 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,953
  2. Avatar for Gargleblasters 2. Gargleblasters 78 pts. 10,902
  3. Avatar for Beta Folders 3. Beta Folders 60 pts. 10,897
  4. Avatar for Go Science 4. Go Science 45 pts. 10,881
  5. Avatar for Contenders 5. Contenders 33 pts. 10,712
  6. Avatar for Void Crushers 6. Void Crushers 24 pts. 10,633
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 17 pts. 10,573
  8. Avatar for Italiani Al Lavoro 8. Italiani Al Lavoro 12 pts. 9,005
  9. Avatar for HMT heritage 9. HMT heritage 8 pts. 8,734
  10. Avatar for Team South Africa 10. Team South Africa 6 pts. 8,626
  1. Avatar for JUMELLE54 81. JUMELLE54 Lv 1 3 pts. 8,165
  2. Avatar for sammiibee16 82. sammiibee16 Lv 1 2 pts. 8,096
  3. Avatar for ViJay7019 83. ViJay7019 Lv 1 2 pts. 7,969
  4. Avatar for trentis1 84. trentis1 Lv 1 2 pts. 7,968
  5. Avatar for Cerzax 85. Cerzax Lv 1 2 pts. 7,914
  6. Avatar for Spekz183 86. Spekz183 Lv 1 2 pts. 7,884
  7. Avatar for Alistair69 87. Alistair69 Lv 1 2 pts. 7,760
  8. Avatar for rsosborne 88. rsosborne Lv 1 2 pts. 7,722
  9. Avatar for Arne Heessels 89. Arne Heessels Lv 1 2 pts. 7,704
  10. Avatar for Jim Fraser 90. Jim Fraser Lv 1 2 pts. 7,516

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."