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1373: Extra Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
May 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Anthropic Dreams
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  2. Avatar for andrewtmaxwell 52. andrewtmaxwell Lv 1 13 pts. 9,168
  3. Avatar for pfirth 53. pfirth Lv 1 12 pts. 9,076
  4. Avatar for weitzen 54. weitzen Lv 1 11 pts. 9,022
  5. Avatar for Bushman 55. Bushman Lv 1 11 pts. 9,005
  6. Avatar for spritz1992 56. spritz1992 Lv 1 10 pts. 8,982
  7. Avatar for phi16 57. phi16 Lv 1 10 pts. 8,975
  8. Avatar for Merf 58. Merf Lv 1 9 pts. 8,911
  9. Avatar for firejuggler 59. firejuggler Lv 1 9 pts. 8,884
  10. Avatar for froggs554 60. froggs554 Lv 1 8 pts. 8,838

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."