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1578: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 28, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 13,158
  2. Avatar for Contenders 2. Contenders 63 pts. 13,087
  3. Avatar for Gargleblasters 3. Gargleblasters 37 pts. 13,078
  4. Avatar for Beta Folders 4. Beta Folders 21 pts. 12,979
  5. Avatar for Void Crushers 5. Void Crushers 11 pts. 12,864
  6. Avatar for Go Science 6. Go Science 5 pts. 12,842
  7. Avatar for Marvin's bunch 7. Marvin's bunch 2 pts. 12,784
  8. Avatar for Russian team 8. Russian team 1 pt. 12,063
  9. Avatar for HMT heritage 9. HMT heritage 1 pt. 11,791
  10. Avatar for L'Alliance Francophone 10. L'Alliance Francophone 1 pt. 11,718
  1. Avatar for Amphimixus 51. Amphimixus Lv 1 3 pts. 11,756
  2. Avatar for sciencewalker 52. sciencewalker Lv 1 2 pts. 11,749
  3. Avatar for rabamino12358 53. rabamino12358 Lv 1 2 pts. 11,722
  4. Avatar for christioanchauvin 54. christioanchauvin Lv 1 2 pts. 11,718
  5. Avatar for MicElephant 55. MicElephant Lv 1 2 pts. 11,640
  6. Avatar for lconor 56. lconor Lv 1 2 pts. 11,611
  7. Avatar for cbwest 57. cbwest Lv 1 1 pt. 11,433
  8. Avatar for Vincera 58. Vincera Lv 1 1 pt. 11,411
  9. Avatar for Deleted player 59. Deleted player pts. 11,402
  10. Avatar for kludbrook 60. kludbrook Lv 1 1 pt. 11,294

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +480)
Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.