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1578: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 28, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Anthropic Dreams
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  1. Avatar for DoctorSockrates 61. DoctorSockrates Lv 1 1 pt. 11,186
  2. Avatar for NinjaGreg 62. NinjaGreg Lv 1 1 pt. 11,157
  3. Avatar for Knoblerine 63. Knoblerine Lv 1 1 pt. 11,131
  4. Avatar for mitarcher 64. mitarcher Lv 1 1 pt. 11,021
  5. Avatar for pfirth 65. pfirth Lv 1 1 pt. 11,011
  6. Avatar for ManVsYard 66. ManVsYard Lv 1 1 pt. 10,996
  7. Avatar for asb4 67. asb4 Lv 1 1 pt. 10,990
  8. Avatar for 01010011111 68. 01010011111 Lv 1 1 pt. 10,516
  9. Avatar for Altercomp 69. Altercomp Lv 1 1 pt. 10,374
  10. Avatar for demeter900 70. demeter900 Lv 1 1 pt. 10,334

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +480)
Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.